Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
91_exp13 Exclusive	GWAS_GS	2.38e-01	2.10e-01	3.23e-01	9.73e-04
GWAS_GS Exclusive	91_exp13	5.32e-01	7.24e-01	3.00e-01	9.67e-01
91_exp13 Exclusive	GWAS_GS Exclusive	1.82e-01	1.72e-01	3.10e-01	4.69e-04
GWAS_GS Exclusive	91_exp13 Exclusive	6.26e-01	9.05e-01	3.39e-01	9.21e-01
91_exp13 Exclusive	Overlap	4.55e-01	1.98e-02	9.50e-01	1.58e-01
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	5.93e-04	4.40e-04	1.20e-54	1.09e-05



Evaluating how well 91_exp13 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_exp13 Exclusive	GWAS_GS	0.59	0.81	0.84	0.80	3.08
GWAS_GS Exclusive	91_exp13	0.51	0.54	0.74	0.48	0.33
91_exp13 Exclusive	GWAS_GS Exclusive	0.58	0.95	0.79	0.75	3.03
GWAS_GS Exclusive	91_exp13 Exclusive	0.51	0.57	0.49	0.31	0.11
91_exp13 Exclusive	Overlap	0.93	0.81	641633707883306.00	0.45	1.53
GWAS_GS Exclusive	Overlap	1.00	0.95	98784710366980.00	1.21	1.72
Overlap	Exclusives	0.61	173067469056762.50	4.98	2.40	5.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_exp13 Exclusive	GWAS_GS	0.01	1.03	0.71	0.96	1.16
GWAS_GS Exclusive	91_exp13	0.01	1.14	3.12	2.50	1.10
91_exp13 Exclusive	GWAS_GS Exclusive	0.01	1.13	0.83	0.81	1.90
GWAS_GS Exclusive	91_exp13 Exclusive	0.01	0.75	1.58	1.04	0.64
91_exp13 Exclusive	Overlap	0.00	0.11	5005571383055780.00	-0.27	0.04
GWAS_GS Exclusive	Overlap	0.04	11.53	inf	59.94	223.48
Overlap	Exclusives	0.03	2396907254729334.00	22.87	10.73	19.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
91_exp13 Exclusive	90	90	
GWAS_GS Exclusive	109	104	SLC8A1-AS1;D21S2088E;LINC00158;MIR302F;PCDH11Y
Overlap	1	1