Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
91_Exp13	Ismael_GS	5.79e-01	7.77e-01	7.85e-01	5.09e-02
Ismael_GS	91_Exp13	8.12e-01	3.75e-01	3.05e-04	4.62e-01



Evaluating how well 91_Exp13 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_Exp13	Ismael_GS	0.69	0.60	0.40	0.27	2.24
Ismael_GS	91_Exp13	0.53	1.93	2.00	1.68	1.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_Exp13	Ismael_GS	0.00	0.23	-0.38	-0.27	0.51
Ismael_GS	91_Exp13	0.01	0.38	0.99	0.10	0.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
91_Exp13	91	91	
Ismael_GS	14	14