Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
89_exp14 Exclusive	Tier1_GS	1.58e-01	2.89e-01	2.57e-01	1.24e-02
Tier1_GS Exclusive	89_exp14	4.29e-01	5.76e-01	2.74e-01	6.24e-01
89_exp14 Exclusive	Tier1_GS Exclusive	2.25e-01	2.42e-01	3.95e-01	3.35e-02
Tier1_GS Exclusive	89_exp14 Exclusive	7.13e-01	6.73e-01	5.82e-01	9.11e-01
89_exp14 Exclusive	Overlap	5.55e-01	6.10e-01	6.44e-01	5.55e-01
Tier1_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.87e-03	1.17e-05	6.68e-25	1.62e-05



Evaluating how well 89_exp14 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
89_exp14 Exclusive	Tier1_GS	0.64	1.05	1.59	1.01	3.33
Tier1_GS Exclusive	89_exp14	0.53	1.60	1.23	1.05	0.88
89_exp14 Exclusive	Tier1_GS Exclusive	0.63	1.32	1.78	0.83	3.03
Tier1_GS Exclusive	89_exp14 Exclusive	0.52	1.28	1.25	0.78	0.42
89_exp14 Exclusive	Overlap	0.73	0.23	-0.22	0.00	1.17
Tier1_GS Exclusive	Overlap	1.00	3.46	1.53	2.83	2.42
Overlap	Exclusives	0.63	4.73	5.46	2.84	5.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
89_exp14 Exclusive	Tier1_GS	0.00	1.32	1.62	0.93	3.00
Tier1_GS Exclusive	89_exp14	0.01	2.29	7.12	2.14	3.27
89_exp14 Exclusive	Tier1_GS Exclusive	0.00	1.54	1.22	0.62	1.94
Tier1_GS Exclusive	89_exp14 Exclusive	0.00	0.15	1.86	0.58	0.20
89_exp14 Exclusive	Overlap	0.00	2.25	1.35	1.24	0.24
Tier1_GS Exclusive	Overlap	0.07	92.46	112.55	289.06	168.12
Overlap	Exclusives	0.06	64.81	95.13	14.93	98.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
89_exp14 Exclusive	87	85	NT5C1B-RDH14;AC091959.3
Tier1_GS Exclusive	29	28	MS4A
Overlap	2	2