Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
89_exp14	Tier2_GS	7.52e-01	5.38e-01	7.44e-01	1.12e-01
Tier2_GS	89_exp14	5.05e-01	8.98e-01	7.27e-03	7.32e-01



Evaluating how well 89_exp14 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
89_exp14	Tier2_GS	0.61	-0.06	0.98	0.60	2.28
Tier2_GS	89_exp14	0.52	1.57	1.01	1.00	0.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
89_exp14	Tier2_GS	0.01	3.40	7.42	5.17	3.62
Tier2_GS	89_exp14	0.01	2.82	1.69	2.32	2.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
89_exp14	89	87	AC091959.3;NT5C1B-RDH14
Tier2_GS	46	43	TNSF13;TNSF12;IGH