Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 89_exp14 Tier2_GS 7.52e-01 5.38e-01 7.44e-01 1.12e-01 Tier2_GS 89_exp14 5.05e-01 8.98e-01 7.27e-03 7.32e-01 Evaluating how well 89_exp14 genes are linked to Tier2_GS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 89_exp14 Tier2_GS 0.61 -0.06 0.98 0.60 2.28 Tier2_GS 89_exp14 0.52 1.57 1.01 1.00 0.82 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 89_exp14 Tier2_GS 0.01 3.40 7.42 5.17 3.62 Tier2_GS 89_exp14 0.01 2.82 1.69 2.32 2.61 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 89_exp14 89 87 AC091959.3;NT5C1B-RDH14 Tier2_GS 46 43 TNSF13;TNSF12;IGH