Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
89_exp14 Exclusive	GWAS_GS	5.31e-02	1.88e-01	1.04e-01	1.30e-04
GWAS_GS Exclusive	89_exp14	4.04e-01	6.75e-01	2.69e-01	6.57e-01
89_exp14 Exclusive	GWAS_GS Exclusive	6.98e-02	2.02e-01	1.39e-01	5.74e-04
GWAS_GS Exclusive	89_exp14 Exclusive	7.10e-01	8.17e-01	3.70e-01	9.28e-01
89_exp14 Exclusive	Overlap	8.57e-01	9.08e-01	8.13e-01	3.42e-01
GWAS_GS Exclusive	Overlap	4.00e-02	7.71e-02	8.03e-03	5.77e-03
Overlap	Exclusives	5.85e-04	4.27e-06	6.05e-23	2.21e-08



Evaluating how well 89_exp14 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
89_exp14 Exclusive	GWAS_GS	0.60	1.64	1.78	1.04	4.16
GWAS_GS Exclusive	89_exp14	0.53	1.25	1.07	0.94	1.15
89_exp14 Exclusive	GWAS_GS Exclusive	0.60	1.55	1.57	1.23	3.46
GWAS_GS Exclusive	89_exp14 Exclusive	0.51	0.97	0.89	0.60	0.54
89_exp14 Exclusive	Overlap	0.71	0.40	-0.00	0.66	1.40
GWAS_GS Exclusive	Overlap	0.96	3.12	1.95	2.57	2.65
Overlap	Exclusives	0.64	4.55	6.45	3.43	7.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
89_exp14 Exclusive	GWAS_GS	0.01	2.68	2.51	1.28	1.89
GWAS_GS Exclusive	89_exp14	0.01	13.17	10.18	8.94	6.58
89_exp14 Exclusive	GWAS_GS Exclusive	0.01	2.39	1.98	1.36	1.91
GWAS_GS Exclusive	89_exp14 Exclusive	0.01	1.95	3.81	2.93	0.95
89_exp14 Exclusive	Overlap	0.00	0.92	0.07	1.22	1.66
GWAS_GS Exclusive	Overlap	0.07	106.16	294.25	184.14	110.07
Overlap	Exclusives	0.04	25.50	41.90	17.52	38.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
89_exp14 Exclusive	86	84	AC091959.3;NT5C1B-RDH14
GWAS_GS Exclusive	107	102	LINC00158;D21S2088E;MIR302F;SLC8A1-AS1;PCDH11Y
Overlap	3	3