Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
89_Exp14	Ismael_GS	9.26e-02	1.61e-01	1.57e-01	9.98e-03
Ismael_GS	89_Exp14	6.93e-01	8.81e-02	5.12e-05	8.17e-02



Evaluating how well 89_Exp14 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
89_Exp14	Ismael_GS	0.74	1.27	2.19	0.97	2.88
Ismael_GS	89_Exp14	0.54	3.63	1.66	2.39	1.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
89_Exp14	Ismael_GS	0.00	2.20	4.33	1.40	0.71
Ismael_GS	89_Exp14	0.01	3.51	0.91	1.30	1.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
89_Exp14	89	87	NT5C1B-RDH14;AC091959.3
Ismael_GS	14	14