Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
98_exp15 Exclusive	tier1_GS	5.56e-01	3.89e-01	3.94e-01	8.54e-01
tier1_GS Exclusive	98_exp15	1.87e-02	5.82e-01	5.67e-01	4.60e-01
98_exp15 Exclusive	tier1_GS Exclusive	6.77e-01	2.76e-01	2.15e-01	8.72e-01
tier1_GS Exclusive	98_exp15 Exclusive	9.65e-03	6.59e-01	5.76e-01	3.90e-01
98_exp15 Exclusive	Overlap	3.56e-01	1.98e-02	5.35e-01	3.96e-02
tier1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.07e-04	1.12e-03	7.64e-33	9.44e-04



Evaluating how well 98_exp15 genes are linked to tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_exp15 Exclusive	tier1_GS	0.54	-0.75	-1.36	-0.73	0.54
tier1_GS Exclusive	98_exp15	0.49	-0.76	-0.41	-0.28	-0.38
98_exp15 Exclusive	tier1_GS Exclusive	0.53	-0.60	-1.54	-0.84	0.58
tier1_GS Exclusive	98_exp15 Exclusive	0.48	-1.05	-0.41	-0.40	-0.56
98_exp15 Exclusive	Overlap	0.96	0.90	inf	0.78	1.64
tier1_GS Exclusive	Overlap	1.00	1.44	inf	1.55	1.60
Overlap	Exclusives	0.59	462769244859892.00	3.82	2.34	3.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_exp15 Exclusive	tier1_GS	0.00	-0.44	-1.31	-0.74	-0.16
tier1_GS Exclusive	98_exp15	0.01	-0.51	-0.18	-0.17	-0.20
98_exp15 Exclusive	tier1_GS Exclusive	0.00	-0.43	-1.30	-0.45	-0.37
tier1_GS Exclusive	98_exp15 Exclusive	0.00	-0.54	-0.56	-0.48	-0.74
98_exp15 Exclusive	Overlap	0.00	0.37	2017839980911181.50	-0.02	0.51
tier1_GS Exclusive	Overlap	0.02	28.49	151272923003761312.00	70.19	14.14
Overlap	Exclusives	0.02	18712710280296304.00	27.71	19.38	27.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
98_exp15 Exclusive	97	97	
tier1_GS Exclusive	30	29	MS4A
Overlap	1	1