Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
98_exp15	tier2_-GS	9.57e-01	9.77e-01	9.80e-01	1.71e-01
tier2_-GS	98_exp15	3.46e-01	6.69e-01	6.91e-03	7.52e-01



Evaluating how well 98_exp15 genes are linked to tier2_-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_exp15	tier2_-GS	0.59	-0.78	0.14	-0.16	2.10
tier2_-GS	98_exp15	0.49	-0.21	-0.52	-0.03	-0.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_exp15	tier2_-GS	0.00	-0.65	-0.23	-0.39	0.94
tier2_-GS	98_exp15	0.01	-0.20	-0.49	-0.17	-0.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
98_exp15	98	98	
tier2_-GS	46	43	TNSF13;TNSF12;IGH