Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
98_exp15 Exclusive	GWAS_GS	2.31e-01	4.52e-01	4.12e-01	3.32e-03
GWAS_GS Exclusive	98_exp15	6.41e-01	7.64e-01	2.88e-01	9.41e-01
98_exp15 Exclusive	GWAS_GS Exclusive	3.16e-01	4.40e-01	5.25e-01	2.71e-03
GWAS_GS Exclusive	98_exp15 Exclusive	6.04e-01	8.51e-01	1.69e-01	8.69e-01
98_exp15 Exclusive	Overlap	2.77e-01	1.98e-02	5.94e-01	5.94e-02
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.34e-04	3.02e-04	2.22e-56	1.60e-05



Evaluating how well 98_exp15 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_exp15 Exclusive	GWAS_GS	0.59	0.63	0.77	0.74	3.22
GWAS_GS Exclusive	98_exp15	0.51	0.72	0.59	0.38	0.35
98_exp15 Exclusive	GWAS_GS Exclusive	0.58	0.54	0.92	0.54	3.34
GWAS_GS Exclusive	98_exp15 Exclusive	0.51	0.80	0.61	0.68	0.08
98_exp15 Exclusive	Overlap	0.96	0.94	inf	0.77	1.82
GWAS_GS Exclusive	Overlap	1.00	1.17	98784710366980.00	1.33	1.70
Overlap	Exclusives	0.61	386007240652795.00	5.07	2.54	6.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_exp15 Exclusive	GWAS_GS	0.01	0.08	0.21	0.30	0.80
GWAS_GS Exclusive	98_exp15	0.01	3.22	1.66	0.59	1.72
98_exp15 Exclusive	GWAS_GS Exclusive	0.01	0.03	0.44	0.24	1.80
GWAS_GS Exclusive	98_exp15 Exclusive	0.01	0.84	0.76	0.24	0.14
98_exp15 Exclusive	Overlap	0.00	0.21	2017839980911181.50	0.13	2.07
GWAS_GS Exclusive	Overlap	0.04	29.78	inf	64.94	42.89
Overlap	Exclusives	0.03	4692493197721622.00	23.65	7.81	27.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
98_exp15 Exclusive	97	97	
GWAS_GS Exclusive	109	104	MIR302F;PCDH11Y;LINC00158;D21S2088E;SLC8A1-AS1
Overlap	1	1