Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
98_exp15	Ismael_GS	9.03e-01	7.98e-01	9.96e-01	2.94e-01
Ismael_GS	98_exp15	5.24e-02	8.62e-01	7.16e-05	7.56e-01



Evaluating how well 98_exp15 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_exp15	Ismael_GS	0.63	-0.26	-0.61	0.03	2.04
Ismael_GS	98_exp15	0.51	1.00	0.42	0.83	0.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_exp15	Ismael_GS	0.00	0.08	0.34	0.06	2.25
Ismael_GS	98_exp15	0.01	0.21	0.01	-0.08	0.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
98_exp15	98	98	
Ismael_GS	14	14