Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
119_exp16	Tier2_GS	3.66e-01	2.09e-01	3.74e-02	1.35e-03
Tier2_GS	119_exp16	4.68e-02	4.68e-01	4.25e-03	5.38e-01



Evaluating how well 119_exp16 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
119_exp16	Tier2_GS	0.65	0.99	1.23	1.43	3.63
Tier2_GS	119_exp16	0.52	-0.57	-0.27	0.16	0.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
119_exp16	Tier2_GS	0.00	0.46	0.49	1.35	3.55
Tier2_GS	119_exp16	0.02	12.67	11.44	14.15	16.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
119_exp16	119	119	
Tier2_GS	46	43	TNSF12;IGH;TNSF13