Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
119_exp16 Exclusive	GWAS_GS	2.16e-01	6.32e-01	1.81e-01	3.16e-03
GWAS_GS Exclusive	119_exp16	3.43e-01	7.34e-01	1.37e-01	5.06e-01
119_exp16 Exclusive	GWAS_GS Exclusive	3.25e-01	6.00e-01	3.76e-01	2.43e-03
GWAS_GS Exclusive	119_exp16 Exclusive	3.71e-01	8.79e-01	1.32e-01	5.00e-01
119_exp16 Exclusive	Overlap	8.17e-01	5.55e-01	9.09e-01	3.04e-01
GWAS_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.32e-04	9.78e-05	3.74e-24	1.94e-05



Evaluating how well 119_exp16 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
119_exp16 Exclusive	GWAS_GS	0.60	1.84	1.31	1.46	3.50
GWAS_GS Exclusive	119_exp16	0.53	0.64	1.03	0.88	1.08
119_exp16 Exclusive	GWAS_GS Exclusive	0.60	1.51	1.09	0.99	3.61
GWAS_GS Exclusive	119_exp16 Exclusive	0.52	0.60	0.80	0.76	0.83
119_exp16 Exclusive	Overlap	0.78	0.63	0.34	0.60	1.33
GWAS_GS Exclusive	Overlap	1.00	2.62	2.02	2.31	2.51
Overlap	Exclusives	0.61	4.68	3.86	2.56	5.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
119_exp16 Exclusive	GWAS_GS	0.01	2.77	1.76	1.95	2.96
GWAS_GS Exclusive	119_exp16	0.01	3.78	8.09	7.55	3.38
119_exp16 Exclusive	GWAS_GS Exclusive	0.01	1.70	1.68	1.31	3.13
GWAS_GS Exclusive	119_exp16 Exclusive	0.01	1.70	2.38	2.44	2.07
119_exp16 Exclusive	Overlap	0.00	0.20	-0.20	-0.08	-0.03
GWAS_GS Exclusive	Overlap	0.10	157.69	180.76	233.77	268.15
Overlap	Exclusives	0.04	42.63	33.84	25.27	38.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
119_exp16 Exclusive	117	117	
GWAS_GS Exclusive	108	103	LINC00158;SLC8A1-AS1;PCDH11Y;MIR302F;D21S2088E
Overlap	2	2