Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
119_Exp16	Ismael_GS	8.97e-01	6.66e-01	8.91e-01	1.30e-01
Ismael_GS	119_Exp16	4.85e-02	8.03e-01	1.11e-04	6.22e-01



Evaluating how well 119_Exp16 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
119_Exp16	Ismael_GS	0.68	0.44	0.02	0.34	2.11
Ismael_GS	119_Exp16	0.53	0.75	1.02	1.14	1.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
119_Exp16	Ismael_GS	0.00	-0.09	-0.84	-0.16	1.53
Ismael_GS	119_Exp16	0.01	-0.04	0.46	0.33	0.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
119_Exp16	119	119	
Ismael_GS	14	14