Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
90_exp1_CERAD Exclusive	tier1_GS	6.29e-01	4.31e-01	8.82e-01	8.98e-02
tier1_GS Exclusive	90_exp1_CERAD	6.45e-01	2.48e-01	1.10e-01	1.53e-02
90_exp1_CERAD Exclusive	tier1_GS Exclusive	7.92e-01	4.75e-01	8.39e-01	8.77e-02
tier1_GS Exclusive	90_exp1_CERAD Exclusive	8.03e-01	3.00e-01	1.72e-01	3.14e-02
90_exp1_CERAD Exclusive	Overlap	2.57e-01	1.98e-02	7.92e-02	1.98e-02
tier1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	2.91e-02	6.07e-05	2.46e-30	1.28e-05



Evaluating how well 90_exp1_CERAD genes are linked to tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp1_CERAD Exclusive	tier1_GS	0.61	0.63	1.28	0.14	2.14
tier1_GS Exclusive	90_exp1_CERAD	0.57	2.31	1.82	1.82	2.10
90_exp1_CERAD Exclusive	tier1_GS Exclusive	0.60	0.42	1.09	0.36	2.01
tier1_GS Exclusive	90_exp1_CERAD Exclusive	0.56	2.02	1.66	1.79	1.91
90_exp1_CERAD Exclusive	Overlap	0.97	0.92	-13559425788388.00	1.14	1.81
tier1_GS Exclusive	Overlap	1.00	1.21	inf	1.53	1.65
Overlap	Exclusives	0.65	250906722156442.00	5.11	1.98	6.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp1_CERAD Exclusive	tier1_GS	0.00	0.44	0.77	-0.13	0.78
tier1_GS Exclusive	90_exp1_CERAD	0.01	2.06	1.14	1.30	1.27
90_exp1_CERAD Exclusive	tier1_GS Exclusive	0.00	-0.01	0.40	-0.04	0.39
tier1_GS Exclusive	90_exp1_CERAD Exclusive	0.00	0.97	0.77	0.64	0.13
90_exp1_CERAD Exclusive	Overlap	0.00	0.13	-618259919720750.00	2.39	8.89
tier1_GS Exclusive	Overlap	0.02	45.67	151272923003761312.00	46.15	0.59
Overlap	Exclusives	0.02	6088974022498169.00	15.89	8.10	11.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
90_exp1_CERAD Exclusive	79	79	
tier1_GS Exclusive	30	29	MS4A
Overlap	1	1