Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
90_exp1_CERAD	tier2_-GS	1.26e-01	9.87e-02	8.09e-02	2.77e-02
tier2_-GS	90_exp1_CERAD	2.83e-01	2.43e-01	2.16e-02	2.10e-01



Evaluating how well 90_exp1_CERAD genes are linked to tier2_-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp1_CERAD	tier2_-GS	0.62	0.40	0.79	0.53	2.54
tier2_-GS	90_exp1_CERAD	0.56	1.20	1.53	1.02	1.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp1_CERAD	tier2_-GS	0.00	2.24	2.99	2.27	3.78
tier2_-GS	90_exp1_CERAD	0.01	0.83	0.92	0.71	1.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
90_exp1_CERAD	80	80	
tier2_-GS	46	43	TNSF12;IGH;TNSF13