Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
90_exp1_CERAD Exclusive	GWAS_GS	5.48e-01	6.52e-01	5.48e-01	3.36e-03
GWAS_GS Exclusive	90_exp1_CERAD	5.81e-01	2.79e-01	2.81e-02	1.76e-01
90_exp1_CERAD Exclusive	GWAS_GS Exclusive	5.71e-01	7.20e-01	6.08e-01	5.39e-03
GWAS_GS Exclusive	90_exp1_CERAD Exclusive	4.85e-01	2.56e-01	3.53e-02	1.93e-01
90_exp1_CERAD Exclusive	Overlap	2.97e-01	1.98e-02	2.18e-01	7.92e-02
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.56e-03	5.44e-06	1.12e-57	2.54e-08



Evaluating how well 90_exp1_CERAD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp1_CERAD Exclusive	GWAS_GS	0.59	1.11	1.45	0.82	2.79
GWAS_GS Exclusive	90_exp1_CERAD	0.55	1.73	1.55	1.54	1.91
90_exp1_CERAD Exclusive	GWAS_GS Exclusive	0.59	0.94	1.23	0.70	2.65
GWAS_GS Exclusive	90_exp1_CERAD Exclusive	0.55	2.03	1.50	1.52	1.61
90_exp1_CERAD Exclusive	Overlap	0.97	0.99	-13559425788388.00	1.01	1.57
GWAS_GS Exclusive	Overlap	1.00	1.11	98784710366980.00	1.27	1.76
Overlap	Exclusives	0.65	401312409383990.00	5.98	2.55	7.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp1_CERAD Exclusive	GWAS_GS	0.01	1.09	0.99	0.80	1.95
GWAS_GS Exclusive	90_exp1_CERAD	0.01	2.37	2.19	2.29	1.96
90_exp1_CERAD Exclusive	GWAS_GS Exclusive	0.01	1.08	1.15	0.61	2.24
GWAS_GS Exclusive	90_exp1_CERAD Exclusive	0.00	1.54	1.19	0.98	0.29
90_exp1_CERAD Exclusive	Overlap	0.00	0.77	-618259919720750.00	1.10	2.52
GWAS_GS Exclusive	Overlap	0.04	9.51	inf	79.52	288.44
Overlap	Exclusives	0.03	inf	21.15	8.48	22.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
90_exp1_CERAD Exclusive	79	79	
GWAS_GS Exclusive	109	104	LINC00158;D21S2088E;MIR302F;PCDH11Y;SLC8A1-AS1
Overlap	1	1