Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
90_exp1_CERAD	Ismael_GS	4.16e-01	1.32e-01	2.88e-01	5.48e-02
Ismael_GS	90_exp1_CERAD	7.65e-02	5.70e-01	1.47e-06	4.26e-02



Evaluating how well 90_exp1_CERAD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp1_CERAD	Ismael_GS	0.70	0.50	1.50	0.63	2.72
Ismael_GS	90_exp1_CERAD	0.54	1.66	0.63	0.71	1.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp1_CERAD	Ismael_GS	0.00	0.13	2.06	0.06	1.03
Ismael_GS	90_exp1_CERAD	0.00	1.13	0.35	0.00	0.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
90_exp1_CERAD	80	80	
Ismael_GS	14	14