Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
63_exp2_CERAD	Tier1_GS	1.98e-01	3.34e-01	5.18e-01	3.24e-02
Tier1_GS	63_exp2_CERAD	5.53e-01	4.58e-01	2.84e-01	3.01e-01



Evaluating how well 63_exp2_CERAD genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
63_exp2_CERAD	Tier1_GS	0.63	0.96	1.60	0.55	2.66
Tier1_GS	63_exp2_CERAD	0.55	0.98	1.16	1.19	1.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
63_exp2_CERAD	Tier1_GS	0.00	0.74	0.35	0.04	0.87
Tier1_GS	63_exp2_CERAD	0.00	0.49	0.88	0.59	0.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
63_exp2_CERAD	63	63	
Tier1_GS	31	30	MS4A