Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
63_exp2_CERAD	Tier2_GS	6.27e-01	4.44e-01	6.68e-01	5.93e-02
Tier2_GS	63_exp2_CERAD	6.67e-01	3.52e-01	1.10e-02	4.60e-01



Evaluating how well 63_exp2_CERAD genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
63_exp2_CERAD	Tier2_GS	0.62	1.16	1.13	0.78	2.59
Tier2_GS	63_exp2_CERAD	0.56	1.23	1.81	1.59	1.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
63_exp2_CERAD	Tier2_GS	0.00	1.17	0.68	0.60	1.76
Tier2_GS	63_exp2_CERAD	0.00	0.22	1.00	0.54	0.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
63_exp2_CERAD	63	63	
Tier2_GS	46	43	TNSF12;IGH;TNSF13