Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 63_exp2_CERAD Tier2_GS 6.27e-01 4.44e-01 6.68e-01 5.93e-02 Tier2_GS 63_exp2_CERAD 6.67e-01 3.52e-01 1.10e-02 4.60e-01 Evaluating how well 63_exp2_CERAD genes are linked to Tier2_GS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 63_exp2_CERAD Tier2_GS 0.62 1.16 1.13 0.78 2.59 Tier2_GS 63_exp2_CERAD 0.56 1.23 1.81 1.59 1.68 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 63_exp2_CERAD Tier2_GS 0.00 1.17 0.68 0.60 1.76 Tier2_GS 63_exp2_CERAD 0.00 0.22 1.00 0.54 0.38 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 63_exp2_CERAD 63 63 Tier2_GS 46 43 TNSF12;IGH;TNSF13