Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
63_exp2_CERAD	GWAS_GS	9.90e-01	7.30e-01	9.81e-01	9.80e-02
GWAS_GS	63_exp2_CERAD	6.46e-01	9.51e-01	7.09e-01	8.84e-01



Evaluating how well 63_exp2_CERAD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
63_exp2_CERAD	GWAS_GS	0.56	-0.19	-1.05	-0.52	2.11
GWAS_GS	63_exp2_CERAD	0.52	-0.11	0.11	0.08	0.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
63_exp2_CERAD	GWAS_GS	0.01	-0.35	-1.21	-0.56	0.70
GWAS_GS	63_exp2_CERAD	0.00	-0.56	-0.52	-0.52	-0.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
63_exp2_CERAD	63	63	
GWAS_GS	110	105	SLC8A1-AS1;LINC00158;PCDH11Y;MIR302F;D21S2088E