Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
63_Exp2_CERAD	Ismael_GS	4.76e-01	3.75e-01	3.43e-01	6.79e-01
Ismael_GS	63_Exp2_CERAD	1.87e-02	9.74e-01	6.57e-03	7.92e-01



Evaluating how well 63_Exp2_CERAD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
63_Exp2_CERAD	Ismael_GS	0.56	-0.71	-1.38	-0.91	0.66
Ismael_GS	63_Exp2_CERAD	0.51	0.06	0.23	-0.07	0.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
63_Exp2_CERAD	Ismael_GS	0.00	-0.37	-1.13	-0.75	-0.17
Ismael_GS	63_Exp2_CERAD	0.00	-0.44	-0.36	-0.59	-0.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
63_Exp2_CERAD	63	63	
Ismael_GS	14	14