Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
91_exp17 Exclusive	Tier2_GS	9.19e-01	6.65e-01	6.94e-01	3.14e-02
Tier2_GS Exclusive	91_exp17	5.72e-01	2.86e-01	2.12e-02	3.64e-01
91_exp17 Exclusive	Tier2_GS Exclusive	8.99e-01	6.64e-01	5.25e-01	2.59e-02
Tier2_GS Exclusive	91_exp17 Exclusive	6.99e-01	4.11e-01	3.77e-02	4.54e-01
91_exp17 Exclusive	Overlap	2.57e-01	3.17e-01	2.38e-01	2.77e-01
Tier2_GS Exclusive	Overlap	7.92e-02	9.90e-02	9.90e-02	2.38e-01
Overlap	Exclusives	7.36e-04	3.03e-02	6.57e-01	1.19e-03



Evaluating how well 91_exp17 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_exp17 Exclusive	Tier2_GS	0.61	0.25	0.45	0.41	2.29
Tier2_GS Exclusive	91_exp17	0.52	0.53	0.55	0.37	0.76
91_exp17 Exclusive	Tier2_GS Exclusive	0.62	0.18	0.68	0.69	2.50
Tier2_GS Exclusive	91_exp17 Exclusive	0.52	0.21	0.23	0.06	0.60
91_exp17 Exclusive	Overlap	0.14	-1.02	-1.05	-1.08	-1.28
Tier2_GS Exclusive	Overlap	0.89	3.04	1.97	1.66	1.45
Overlap	Exclusives	0.59	1.64	2.52	1.42	3.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_exp17 Exclusive	Tier2_GS	0.00	-0.41	-0.18	-0.21	2.12
Tier2_GS Exclusive	91_exp17	0.01	0.24	0.17	0.12	0.28
91_exp17 Exclusive	Tier2_GS Exclusive	0.00	-0.59	-0.04	-0.16	0.84
Tier2_GS Exclusive	91_exp17 Exclusive	0.00	0.13	-0.09	0.20	0.19
91_exp17 Exclusive	Overlap	0.00	-0.41	-0.58	-0.36	-0.44
Tier2_GS Exclusive	Overlap	0.00	0.65	2.65	0.20	0.18
Overlap	Exclusives	0.01	2.07	4.35	1.63	3.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
91_exp17 Exclusive	90	89	RFPL2
Tier2_GS Exclusive	45	42	TNSF12;IGH;TNSF13
Overlap	1	1