Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
91_exp17	Ismael_GS	5.57e-02	1.20e-02	4.12e-02	1.38e-03
Ismael_GS	91_exp17	5.79e-01	1.97e-01	5.54e-07	6.70e-02



Evaluating how well 91_exp17 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_exp17	Ismael_GS	0.79	1.86	2.80	1.50	3.30
Ismael_GS	91_exp17	0.56	3.29	1.87	1.79	1.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_exp17	Ismael_GS	0.00	0.96	4.15	1.18	0.69
Ismael_GS	91_exp17	0.01	2.60	1.85	2.26	0.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
91_exp17	91	90	RFPL2
Ismael_GS	14	14