Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
49_exp18	tier2_-GS	9.25e-01	9.44e-01	9.61e-01	1.46e-01
tier2_-GS	49_exp18	8.53e-01	7.58e-01	2.08e-01	8.55e-01



Evaluating how well 49_exp18 genes are linked to tier2_-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
49_exp18	tier2_-GS	0.60	0.06	0.36	0.20	2.12
tier2_-GS	49_exp18	0.52	0.50	-0.14	-0.20	0.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
49_exp18	tier2_-GS	0.00	0.09	0.80	0.31	1.90
tier2_-GS	49_exp18	0.00	0.40	-0.20	-0.16	-0.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
49_exp18	49	49	
tier2_-GS	46	43	IGH;TNSF12;TNSF13