Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
49_exp18	GWAS_GS	9.29e-01	4.85e-01	4.65e-01	1.70e-02
GWAS_GS	49_exp18	8.85e-01	5.63e-01	2.26e-01	2.38e-01



Evaluating how well 49_exp18 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
49_exp18	GWAS_GS	0.58	0.15	0.62	0.74	3.05
GWAS_GS	49_exp18	0.55	1.10	0.78	1.03	1.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
49_exp18	GWAS_GS	0.01	-0.18	0.40	0.43	0.80
GWAS_GS	49_exp18	0.00	0.14	-0.22	-0.02	-0.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
49_exp18	49	49	
GWAS_GS	110	105	LINC00158;MIR302F;D21S2088E;PCDH11Y;SLC8A1-AS1