Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
49_exp19	Ismael_GS	5.44e-01	4.28e-01	8.34e-01	6.82e-02
Ismael_GS	49_exp19	5.68e-01	4.30e-01	4.08e-04	1.14e-01



Evaluating how well 49_exp19 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
49_exp19	Ismael_GS	0.64	-0.11	-0.20	0.01	1.85
Ismael_GS	49_exp19	0.56	2.35	1.37	0.95	1.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
49_exp19	Ismael_GS	0.00	-0.35	-0.27	-0.40	0.11
Ismael_GS	49_exp19	0.00	0.15	0.15	-0.11	-0.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
49_exp19	49	49	
Ismael_GS	14	14