Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 77_exp19 Exclusive Tier1_GS 7.51e-01 5.65e-01 3.53e-01 1.46e-01 Tier1_GS Exclusive 77_exp19 3.45e-01 5.04e-01 5.59e-01 4.48e-01 77_exp19 Exclusive Tier1_GS Exclusive 8.62e-01 4.33e-01 4.31e-01 2.36e-01 Tier1_GS Exclusive 77_exp19 Exclusive 4.04e-01 5.21e-01 7.28e-01 7.52e-01 77_exp19 Exclusive Overlap 1.58e-01 1.98e-02 3.17e-01 7.92e-02 Tier1_GS Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 1.76e-03 1.10e-04 1.05e-28 1.74e-05 Evaluating how well 77_exp19 genes are linked to Tier1_GS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 77_exp19 Exclusive Tier1_GS 0.57 -0.05 -0.20 -0.33 1.54 Tier1_GS Exclusive 77_exp19 0.51 0.72 0.76 0.29 0.36 77_exp19 Exclusive Tier1_GS Exclusive 0.56 -0.05 -0.23 -0.34 1.27 Tier1_GS Exclusive 77_exp19 Exclusive 0.50 0.89 0.63 0.16 -0.12 77_exp19 Exclusive Overlap 0.96 1.12 81339665264942.00 0.96 1.60 Tier1_GS Exclusive Overlap 1.00 1.35 inf 1.60 1.71 Overlap Exclusives 0.62 181201338028242.00 5.14 2.85 4.45 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 77_exp19 Exclusive Tier1_GS 0.01 8.65 16.26 4.98 11.82 Tier1_GS Exclusive 77_exp19 0.00 0.19 0.59 1.58 1.54 77_exp19 Exclusive Tier1_GS Exclusive 0.01 4.85 12.77 8.87 5.35 Tier1_GS Exclusive 77_exp19 Exclusive 0.00 -0.09 -0.09 0.05 -0.13 77_exp19 Exclusive Overlap 0.00 1.50 657487596588127.50 0.53 2.65 Tier1_GS Exclusive Overlap 0.02 37.30 151272923003761312.00 32.34 26.04 Overlap Exclusives 0.02 5536715319560103.00 19.55 10.33 10.01 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 77_exp19 Exclusive 76 75 RFPL2 Tier1_GS Exclusive 30 29 MS4A Overlap 1 1