Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
77_exp19	Tier2_GS	7.78e-02	4.00e-01	3.66e-01	7.27e-01
Tier2_GS	77_exp19	5.71e-01	5.67e-01	3.35e-01	6.40e-01



Evaluating how well 77_exp19 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
77_exp19	Tier2_GS	0.55	-1.67	-0.86	-1.06	1.00
Tier2_GS	77_exp19	0.47	-0.58	-1.47	-1.18	-0.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
77_exp19	Tier2_GS	0.00	-1.24	-0.29	-0.72	-0.01
Tier2_GS	77_exp19	0.00	-0.19	-1.04	-0.62	-0.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
77_exp19	77	76	RFPL2
Tier2_GS	46	43	TNSF12;TNSF13;IGH