Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
77_exp19 Exclusive	GWAS_GS	9.71e-01	7.88e-01	7.62e-01	1.70e-01
GWAS_GS Exclusive	77_exp19	3.66e-01	9.13e-01	6.43e-01	9.77e-01
77_exp19 Exclusive	GWAS_GS Exclusive	9.97e-01	6.53e-01	8.46e-01	1.74e-01
GWAS_GS Exclusive	77_exp19 Exclusive	3.93e-01	9.28e-01	6.43e-01	9.91e-01
77_exp19 Exclusive	Overlap	2.57e-01	1.98e-02	2.77e-01	7.92e-02
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.01e-03	2.01e-05	2.71e-46	6.42e-08



Evaluating how well 77_exp19 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
77_exp19 Exclusive	GWAS_GS	0.56	0.22	-0.68	-0.26	2.04
GWAS_GS Exclusive	77_exp19	0.49	-0.71	-0.30	-0.12	-0.29
77_exp19 Exclusive	GWAS_GS Exclusive	0.56	0.10	-0.95	-0.32	1.92
GWAS_GS Exclusive	77_exp19 Exclusive	0.49	-0.60	-0.27	-0.16	-0.39
77_exp19 Exclusive	Overlap	0.96	1.16	81339665264942.00	0.92	1.72
GWAS_GS Exclusive	Overlap	1.00	1.11	98784710366980.00	1.27	1.86
Overlap	Exclusives	0.64	inf	5.60	3.04	6.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
77_exp19 Exclusive	GWAS_GS	0.01	1.91	3.13	1.75	1.09
GWAS_GS Exclusive	77_exp19	0.01	1.11	1.35	3.34	1.12
77_exp19 Exclusive	GWAS_GS Exclusive	0.01	1.60	2.70	1.45	4.36
GWAS_GS Exclusive	77_exp19 Exclusive	0.00	0.49	0.21	0.96	0.10
77_exp19 Exclusive	Overlap	0.00	1.09	657487596588127.50	0.24	2.55
GWAS_GS Exclusive	Overlap	0.04	20.11	inf	70.44	44.29
Overlap	Exclusives	0.02	2217046311951121.75	20.19	8.33	19.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
77_exp19 Exclusive	76	75	RFPL2
GWAS_GS Exclusive	109	104	LINC00158;D21S2088E;SLC8A1-AS1;PCDH11Y;MIR302F
Overlap	1	1