Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
77_exp19	Ismael_GS	2.59e-02	2.97e-01	9.65e-02	4.66e-04
Ismael_GS	77_exp19	1.93e-02	9.97e-01	7.68e-03	7.90e-01



Evaluating how well 77_exp19 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
77_exp19	Ismael_GS	0.74	1.69	1.63	1.02	3.03
Ismael_GS	77_exp19	0.50	-0.27	0.15	-0.29	-0.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
77_exp19	Ismael_GS	0.00	0.26	0.69	0.11	0.56
Ismael_GS	77_exp19	0.00	0.00	0.68	0.13	-0.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
77_exp19	77	76	RFPL2
Ismael_GS	14	14