Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
76_exp20 Exclusive	tier1_GS	1.26e-01	7.46e-02	5.05e-02	4.52e-01
tier1_GS Exclusive	76_exp20	1.27e-01	7.90e-01	8.51e-01	4.72e-01
76_exp20 Exclusive	tier1_GS Exclusive	9.63e-02	6.45e-02	2.26e-02	4.39e-01
tier1_GS Exclusive	76_exp20 Exclusive	8.77e-02	5.93e-01	6.97e-01	4.01e-01
76_exp20 Exclusive	Overlap	3.17e-01	1.98e-02	3.96e-01	9.90e-02
tier1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.64e-05	3.37e-05	8.04e-32	4.36e-05



Evaluating how well 76_exp20 genes are linked to tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp20 Exclusive	tier1_GS	0.51	-1.01	-1.54	-1.05	0.16
tier1_GS Exclusive	76_exp20	0.50	-0.46	-0.29	-0.29	0.13
76_exp20 Exclusive	tier1_GS Exclusive	0.49	-0.98	-1.98	-1.24	-0.07
tier1_GS Exclusive	76_exp20 Exclusive	0.50	-0.66	-0.45	-0.46	0.10
76_exp20 Exclusive	Overlap	0.96	1.00	1678448667435517.50	0.85	1.64
tier1_GS Exclusive	Overlap	1.00	1.21	inf	1.61	1.71
Overlap	Exclusives	0.63	600086504103614.00	4.92	2.27	4.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp20 Exclusive	tier1_GS	0.00	-0.80	-0.87	-0.80	-0.49
tier1_GS Exclusive	76_exp20	0.00	-0.41	-0.42	-0.39	-0.24
76_exp20 Exclusive	tier1_GS Exclusive	0.00	-0.65	-0.95	-0.92	-0.57
tier1_GS Exclusive	76_exp20 Exclusive	0.00	-1.16	-0.87	-0.94	-0.77
76_exp20 Exclusive	Overlap	0.00	0.76	inf	0.08	0.05
tier1_GS Exclusive	Overlap	0.02	21.04	151272923003761312.00	27.44	10.87
Overlap	Exclusives	0.02	inf	14.51	4.53	8.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
76_exp20 Exclusive	75	75	
tier1_GS Exclusive	30	29	MS4A
Overlap	1	1