Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
76_exp20	tier2_-GS	9.19e-01	8.69e-01	9.14e-01	6.28e-02
tier2_-GS	76_exp20	4.70e-01	8.38e-01	3.10e-01	8.72e-01



Evaluating how well 76_exp20 genes are linked to tier2_-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp20	tier2_-GS	0.59	-0.25	-0.07	-0.28	2.29
tier2_-GS	76_exp20	0.50	-0.54	-0.42	-0.58	-0.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp20	tier2_-GS	0.00	-0.62	-0.22	-0.69	1.74
tier2_-GS	76_exp20	0.00	-0.23	-0.67	-0.44	-0.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
76_exp20	76	76	
tier2_-GS	46	43	TNSF12;IGH;TNSF13