Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
76_exp20 Exclusive	GWAS_GS	4.14e-01	4.07e-01	6.57e-01	8.20e-03
GWAS_GS Exclusive	76_exp20	9.46e-01	6.86e-01	1.40e-01	7.45e-01
76_exp20 Exclusive	GWAS_GS Exclusive	3.88e-01	4.84e-01	6.63e-01	6.05e-03
GWAS_GS Exclusive	76_exp20 Exclusive	9.09e-01	6.55e-01	1.47e-01	8.10e-01
76_exp20 Exclusive	Overlap	2.57e-01	1.98e-02	3.96e-01	5.94e-02
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.58e-04	1.25e-05	8.89e-60	2.27e-07



Evaluating how well 76_exp20 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp20 Exclusive	GWAS_GS	0.59	0.93	1.28	0.81	3.06
GWAS_GS Exclusive	76_exp20	0.53	1.24	0.92	0.79	0.81
76_exp20 Exclusive	GWAS_GS Exclusive	0.58	0.85	1.10	0.62	2.88
GWAS_GS Exclusive	76_exp20 Exclusive	0.52	1.36	0.99	0.84	0.49
76_exp20 Exclusive	Overlap	0.96	1.16	1678448667435517.50	0.98	1.45
GWAS_GS Exclusive	Overlap	1.00	1.28	98784710366980.00	1.15	1.59
Overlap	Exclusives	0.64	456320901994700.00	6.55	3.20	6.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp20 Exclusive	GWAS_GS	0.01	0.36	0.81	0.23	0.50
GWAS_GS Exclusive	76_exp20	0.00	2.39	1.22	1.61	0.32
76_exp20 Exclusive	GWAS_GS Exclusive	0.01	0.09	0.45	-0.03	0.59
GWAS_GS Exclusive	76_exp20 Exclusive	0.00	0.43	0.47	0.28	-0.21
76_exp20 Exclusive	Overlap	0.00	1.43	inf	0.57	3.83
GWAS_GS Exclusive	Overlap	0.04	19.80	inf	37.02	107.71
Overlap	Exclusives	0.02	7489620261857181.00	21.28	8.74	16.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
76_exp20 Exclusive	75	75	
GWAS_GS Exclusive	109	104	PCDH11Y;LINC00158;MIR302F;D21S2088E;SLC8A1-AS1
Overlap	1	1