Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 76_exp20 Exclusive GWAS_GS 4.14e-01 4.07e-01 6.57e-01 8.20e-03 GWAS_GS Exclusive 76_exp20 9.46e-01 6.86e-01 1.40e-01 7.45e-01 76_exp20 Exclusive GWAS_GS Exclusive 3.88e-01 4.84e-01 6.63e-01 6.05e-03 GWAS_GS Exclusive 76_exp20 Exclusive 9.09e-01 6.55e-01 1.47e-01 8.10e-01 76_exp20 Exclusive Overlap 2.57e-01 1.98e-02 3.96e-01 5.94e-02 GWAS_GS Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 1.58e-04 1.25e-05 8.89e-60 2.27e-07 Evaluating how well 76_exp20 genes are linked to GWAS_GS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 76_exp20 Exclusive GWAS_GS 0.59 0.93 1.28 0.81 3.06 GWAS_GS Exclusive 76_exp20 0.53 1.24 0.92 0.79 0.81 76_exp20 Exclusive GWAS_GS Exclusive 0.58 0.85 1.10 0.62 2.88 GWAS_GS Exclusive 76_exp20 Exclusive 0.52 1.36 0.99 0.84 0.49 76_exp20 Exclusive Overlap 0.96 1.16 1678448667435517.50 0.98 1.45 GWAS_GS Exclusive Overlap 1.00 1.28 98784710366980.00 1.15 1.59 Overlap Exclusives 0.64 456320901994700.00 6.55 3.20 6.67 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 76_exp20 Exclusive GWAS_GS 0.01 0.36 0.81 0.23 0.50 GWAS_GS Exclusive 76_exp20 0.00 2.39 1.22 1.61 0.32 76_exp20 Exclusive GWAS_GS Exclusive 0.01 0.09 0.45 -0.03 0.59 GWAS_GS Exclusive 76_exp20 Exclusive 0.00 0.43 0.47 0.28 -0.21 76_exp20 Exclusive Overlap 0.00 1.43 inf 0.57 3.83 GWAS_GS Exclusive Overlap 0.04 19.80 inf 37.02 107.71 Overlap Exclusives 0.02 7489620261857181.00 21.28 8.74 16.13 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 76_exp20 Exclusive 75 75 GWAS_GS Exclusive 109 104 PCDH11Y;LINC00158;MIR302F;D21S2088E;SLC8A1-AS1 Overlap 1 1