Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
76_exp20	Ismael_GS	6.06e-01	6.25e-01	5.66e-01	1.59e-02
Ismael_GS	76_exp20	2.60e-01	7.16e-01	5.47e-04	3.07e-01



Evaluating how well 76_exp20 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp20	Ismael_GS	0.69	0.32	0.61	0.34	2.59
Ismael_GS	76_exp20	0.52	0.49	0.39	0.59	0.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp20	Ismael_GS	0.00	-0.37	-0.42	-0.34	0.32
Ismael_GS	76_exp20	0.00	0.30	-0.05	0.20	-0.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
76_exp20	76	76	
Ismael_GS	14	14