Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
90_exp21 Exclusive	Tier1_GS	5.89e-01	8.63e-01	4.89e-01	7.96e-02
Tier1_GS Exclusive	90_exp21	8.74e-02	7.73e-01	1.80e-01	5.06e-01
90_exp21 Exclusive	Tier1_GS Exclusive	5.86e-01	7.95e-01	5.64e-01	1.51e-01
Tier1_GS Exclusive	90_exp21 Exclusive	1.11e-01	8.43e-01	2.90e-01	4.48e-01
90_exp21 Exclusive	Overlap	3.56e-01	1.98e-02	3.56e-01	3.96e-02
Tier1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	9.67e-04	2.09e-04	9.04e-37	4.89e-05



Evaluating how well 90_exp21 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp21 Exclusive	Tier1_GS	0.61	0.59	0.44	0.25	2.06
Tier1_GS Exclusive	90_exp21	0.52	0.04	0.13	0.23	0.43
90_exp21 Exclusive	Tier1_GS Exclusive	0.60	0.47	0.47	0.19	1.85
Tier1_GS Exclusive	90_exp21 Exclusive	0.51	0.22	0.16	0.07	0.51
90_exp21 Exclusive	Overlap	0.97	0.98	299382369412322.00	0.93	1.65
Tier1_GS Exclusive	Overlap	1.00	1.40	inf	1.76	1.64
Overlap	Exclusives	0.63	inf	4.68	2.73	4.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp21 Exclusive	Tier1_GS	0.00	-0.12	0.19	-0.05	0.88
Tier1_GS Exclusive	90_exp21	0.01	0.64	0.96	0.33	0.79
90_exp21 Exclusive	Tier1_GS Exclusive	0.00	-0.03	0.26	-0.12	0.78
Tier1_GS Exclusive	90_exp21 Exclusive	0.00	0.13	0.20	-0.04	-0.01
90_exp21 Exclusive	Overlap	0.00	0.96	4312701264659164.00	0.39	3.93
Tier1_GS Exclusive	Overlap	0.02	29.99	151272923003761312.00	80.89	83.78
Overlap	Exclusives	0.02	5460551390277524.00	17.76	9.30	18.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
90_exp21 Exclusive	89	88	RFPL2
Tier1_GS Exclusive	30	29	MS4A
Overlap	1	1