Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
90_exp21	Tier2_GS	9.99e-01	7.61e-01	5.31e-01	3.67e-02
Tier2_GS	90_exp21	6.60e-01	7.18e-01	2.58e-02	3.93e-01



Evaluating how well 90_exp21 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp21	Tier2_GS	0.62	0.12	0.95	0.81	3.10
Tier2_GS	90_exp21	0.53	0.83	0.48	0.82	1.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp21	Tier2_GS	0.00	0.13	0.67	0.85	2.23
Tier2_GS	90_exp21	0.01	0.27	-0.24	0.46	0.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
90_exp21	90	89	RFPL2
Tier2_GS	46	43	TNSF12;IGH;TNSF13