Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
90_exp21	Ismael_GS	3.81e-02	2.06e-02	3.52e-02	1.01e-04
Ismael_GS	90_exp21	5.05e-01	9.12e-01	1.89e-04	4.52e-01



Evaluating how well 90_exp21 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp21	Ismael_GS	0.81	2.20	3.84	1.58	3.92
Ismael_GS	90_exp21	0.53	2.36	0.28	0.75	1.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
90_exp21	Ismael_GS	0.00	4.12	15.98	2.59	4.06
Ismael_GS	90_exp21	0.01	5.04	2.50	0.63	1.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
90_exp21	90	89	RFPL2
Ismael_GS	14	14