Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
52_neg_genes_exp17	Ismael_GS	7.64e-01	4.43e-01	3.26e-01	1.73e-01
Ismael_GS	52_neg_genes_exp17	1.50e-01	6.66e-01	9.97e-03	3.19e-01



Evaluating how well 52_neg_genes_exp17 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
52_neg_genes_exp17	Ismael_GS	0.60	-0.28	-0.31	-0.45	1.08
Ismael_GS	52_neg_genes_exp17	0.47	0.78	-0.30	-0.12	-0.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
52_neg_genes_exp17	Ismael_GS	0.00	-0.51	-0.59	-0.48	-0.19
Ismael_GS	52_neg_genes_exp17	0.00	-0.03	-0.45	-0.50	-0.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
52_neg_genes_exp17	52	51	RFPL2
Ismael_GS	14	14