Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
52_neg_genes_exp17 Exclusive	Tier1_GS	7.89e-02	1.53e-01	3.72e-03	2.95e-01
Tier1_GS Exclusive	52_neg_genes_exp17	9.12e-01	7.79e-01	5.80e-01	5.61e-01
52_neg_genes_exp17 Exclusive	Tier1_GS Exclusive	1.39e-01	1.74e-01	1.03e-02	4.81e-01
Tier1_GS Exclusive	52_neg_genes_exp17 Exclusive	7.96e-01	6.67e-01	8.44e-01	4.10e-01
52_neg_genes_exp17 Exclusive	Overlap	8.51e-01	8.91e-01	6.93e-01	9.31e-01
Tier1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.36e-04	1.86e-04	5.67e-04	7.69e-05



Evaluating how well 52_neg_genes_exp17 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
52_neg_genes_exp17 Exclusive	Tier1_GS	0.51	-1.12	-1.44	-1.43	0.19
Tier1_GS Exclusive	52_neg_genes_exp17	0.47	0.71	-0.35	-0.11	-0.91
52_neg_genes_exp17 Exclusive	Tier1_GS Exclusive	0.50	-1.03	-1.47	-1.08	0.07
Tier1_GS Exclusive	52_neg_genes_exp17 Exclusive	0.46	0.38	-0.82	-0.57	-0.88
52_neg_genes_exp17 Exclusive	Overlap	0.51	-0.32	-0.23	-0.31	-0.11
Tier1_GS Exclusive	Overlap	0.99	1.94	1.66	2.04	1.53
Overlap	Exclusives	0.63	2.01	3.51	2.20	3.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
52_neg_genes_exp17 Exclusive	Tier1_GS	0.00	-0.42	-1.08	-1.08	-0.64
Tier1_GS Exclusive	52_neg_genes_exp17	0.00	-0.16	-0.20	-0.46	-0.78
52_neg_genes_exp17 Exclusive	Tier1_GS Exclusive	0.00	-0.46	-0.94	-0.68	-0.20
Tier1_GS Exclusive	52_neg_genes_exp17 Exclusive	0.00	-0.41	-0.24	-0.27	-0.99
52_neg_genes_exp17 Exclusive	Overlap	0.00	-0.41	-0.38	-0.38	-0.27
Tier1_GS Exclusive	Overlap	0.01	28.74	20.65	37.02	12.45
Overlap	Exclusives	0.01	4.97	8.42	3.44	7.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
52_neg_genes_exp17 Exclusive	51	50	RFPL2
Tier1_GS Exclusive	30	29	MS4A
Overlap	1	1