Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 52_neg_genes_exp17 Exclusive Tier1_GS 7.89e-02 1.53e-01 3.72e-03 2.95e-01 Tier1_GS Exclusive 52_neg_genes_exp17 9.12e-01 7.79e-01 5.80e-01 5.61e-01 52_neg_genes_exp17 Exclusive Tier1_GS Exclusive 1.39e-01 1.74e-01 1.03e-02 4.81e-01 Tier1_GS Exclusive 52_neg_genes_exp17 Exclusive 7.96e-01 6.67e-01 8.44e-01 4.10e-01 52_neg_genes_exp17 Exclusive Overlap 8.51e-01 8.91e-01 6.93e-01 9.31e-01 Tier1_GS Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 3.36e-04 1.86e-04 5.67e-04 7.69e-05 Evaluating how well 52_neg_genes_exp17 genes are linked to Tier1_GS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 52_neg_genes_exp17 Exclusive Tier1_GS 0.51 -1.12 -1.44 -1.43 0.19 Tier1_GS Exclusive 52_neg_genes_exp17 0.47 0.71 -0.35 -0.11 -0.91 52_neg_genes_exp17 Exclusive Tier1_GS Exclusive 0.50 -1.03 -1.47 -1.08 0.07 Tier1_GS Exclusive 52_neg_genes_exp17 Exclusive 0.46 0.38 -0.82 -0.57 -0.88 52_neg_genes_exp17 Exclusive Overlap 0.51 -0.32 -0.23 -0.31 -0.11 Tier1_GS Exclusive Overlap 0.99 1.94 1.66 2.04 1.53 Overlap Exclusives 0.63 2.01 3.51 2.20 3.81 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 52_neg_genes_exp17 Exclusive Tier1_GS 0.00 -0.42 -1.08 -1.08 -0.64 Tier1_GS Exclusive 52_neg_genes_exp17 0.00 -0.16 -0.20 -0.46 -0.78 52_neg_genes_exp17 Exclusive Tier1_GS Exclusive 0.00 -0.46 -0.94 -0.68 -0.20 Tier1_GS Exclusive 52_neg_genes_exp17 Exclusive 0.00 -0.41 -0.24 -0.27 -0.99 52_neg_genes_exp17 Exclusive Overlap 0.00 -0.41 -0.38 -0.38 -0.27 Tier1_GS Exclusive Overlap 0.01 28.74 20.65 37.02 12.45 Overlap Exclusives 0.01 4.97 8.42 3.44 7.06 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 52_neg_genes_exp17 Exclusive 51 50 RFPL2 Tier1_GS Exclusive 30 29 MS4A Overlap 1 1