Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_exp22	Ismael_GS	3.86e-01	4.92e-01	6.15e-01	4.24e-02
Ismael_GS	82_exp22	6.70e-02	7.65e-02	8.14e-08	6.20e-02



Evaluating how well 82_exp22 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_exp22	Ismael_GS	0.67	-0.27	1.62	0.25	2.23
Ismael_GS	82_exp22	0.51	1.74	0.10	0.13	0.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_exp22	Ismael_GS	0.00	-0.48	0.49	-0.37	0.06
Ismael_GS	82_exp22	0.00	0.64	-0.23	-0.30	0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_exp22	82	80	RFPL2;ZNF705E
Ismael_GS	14	14