Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_exp22 Exclusive	GWAS_GS	8.21e-01	6.93e-01	4.30e-01	2.84e-02
GWAS_GS Exclusive	82_exp22	3.66e-01	5.85e-01	4.05e-01	6.53e-01
82_exp22 Exclusive	GWAS_GS Exclusive	7.72e-01	6.36e-01	5.37e-01	6.91e-03
GWAS_GS Exclusive	82_exp22 Exclusive	3.31e-01	5.42e-01	4.04e-01	5.13e-01
82_exp22 Exclusive	Overlap	7.52e-01	1.98e-02	9.70e-01	3.17e-01
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	6.66e-04	1.38e-04	3.94e-55	9.82e-08



Evaluating how well 82_exp22 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_exp22 Exclusive	GWAS_GS	0.57	-0.38	0.39	0.07	2.38
GWAS_GS Exclusive	82_exp22	0.52	0.35	0.18	0.02	0.45
82_exp22 Exclusive	GWAS_GS Exclusive	0.57	-0.33	0.29	0.14	2.59
GWAS_GS Exclusive	82_exp22 Exclusive	0.51	0.33	0.50	0.09	0.46
82_exp22 Exclusive	Overlap	0.87	-0.12	-inf	0.05	1.20
GWAS_GS Exclusive	Overlap	1.00	1.04	98784710366980.00	1.16	1.78
Overlap	Exclusives	0.63	407033296689140.00	4.88	2.86	5.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_exp22 Exclusive	GWAS_GS	0.01	-0.33	0.29	-0.03	0.38
GWAS_GS Exclusive	82_exp22	0.01	0.54	2.53	1.67	3.14
82_exp22 Exclusive	GWAS_GS Exclusive	0.01	-0.18	0.14	0.13	0.72
GWAS_GS Exclusive	82_exp22 Exclusive	0.00	0.18	0.47	-0.08	0.35
82_exp22 Exclusive	Overlap	0.00	-0.43	-1003679365728397.00	-0.40	-0.13
GWAS_GS Exclusive	Overlap	0.04	25.54	inf	49.19	346.28
Overlap	Exclusives	0.02	inf	15.18	9.69	17.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_exp22 Exclusive	81	79	ZNF705E;RFPL2
GWAS_GS Exclusive	109	104	D21S2088E;LINC00158;MIR302F;SLC8A1-AS1;PCDH11Y
Overlap	1	1