Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_exp22 Exclusive	Tier2_GS	8.85e-01	3.51e-01	7.32e-01	8.28e-02
Tier2_GS Exclusive	82_exp22	4.62e-01	4.31e-01	7.39e-02	3.42e-01
82_exp22 Exclusive	Tier2_GS Exclusive	9.63e-01	3.93e-01	7.00e-01	6.12e-02
Tier2_GS Exclusive	82_exp22 Exclusive	4.87e-01	3.96e-01	1.42e-01	3.28e-01
82_exp22 Exclusive	Overlap	6.93e-01	4.75e-01	6.14e-01	2.77e-01
Tier2_GS Exclusive	Overlap	7.92e-02	3.96e-02	1.78e-01	2.57e-01
Overlap	Exclusives	5.16e-04	3.31e-03	1.41e-01	6.34e-04



Evaluating how well 82_exp22 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_exp22 Exclusive	Tier2_GS	0.60	-0.90	0.99	0.12	2.40
Tier2_GS Exclusive	82_exp22	0.51	0.49	-0.27	-0.25	0.27
82_exp22 Exclusive	Tier2_GS Exclusive	0.61	-0.59	0.87	0.23	2.38
Tier2_GS Exclusive	82_exp22 Exclusive	0.50	0.26	-0.35	-0.31	-0.11
82_exp22 Exclusive	Overlap	0.16	-0.98	-0.98	-1.03	-1.29
Tier2_GS Exclusive	Overlap	0.89	2.70	2.42	1.53	1.31
Overlap	Exclusives	0.60	2.71	3.43	2.54	3.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_exp22 Exclusive	Tier2_GS	0.00	-0.69	1.14	0.06	2.53
Tier2_GS Exclusive	82_exp22	0.00	1.71	0.19	0.24	0.95
82_exp22 Exclusive	Tier2_GS Exclusive	0.00	-0.44	0.80	0.09	1.92
Tier2_GS Exclusive	82_exp22 Exclusive	0.00	0.18	0.05	-0.08	1.02
82_exp22 Exclusive	Overlap	0.00	-0.23	-0.42	-0.25	-0.33
Tier2_GS Exclusive	Overlap	0.00	1.63	4.79	0.28	0.81
Overlap	Exclusives	0.01	3.78	6.42	3.75	6.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_exp22 Exclusive	81	79	ZNF705E;RFPL2
Tier2_GS Exclusive	45	42	IGH;TNSF13;TNSF12
Overlap	1	1