Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_exp22 Exclusive	Tier1_GS	3.79e-01	1.19e-01	1.76e-01	7.01e-03
Tier1_GS Exclusive	82_exp22	8.51e-01	4.29e-01	3.90e-01	5.28e-01
82_exp22 Exclusive	Tier1_GS Exclusive	3.61e-01	1.42e-01	1.76e-01	1.08e-02
Tier1_GS Exclusive	82_exp22 Exclusive	9.53e-01	5.57e-01	4.29e-01	5.66e-01
82_exp22 Exclusive	Overlap	7.92e-01	1.98e-02	9.70e-01	2.38e-01
Tier1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.29e-03	1.05e-03	2.91e-37	3.95e-04



Evaluating how well 82_exp22 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_exp22 Exclusive	Tier1_GS	0.68	0.85	2.76	1.45	3.52
Tier1_GS Exclusive	82_exp22	0.54	1.82	1.19	1.21	1.35
82_exp22 Exclusive	Tier1_GS Exclusive	0.67	0.88	2.66	1.41	3.19
Tier1_GS Exclusive	82_exp22 Exclusive	0.53	1.85	1.04	1.09	1.06
82_exp22 Exclusive	Overlap	0.87	-0.32	-inf	0.06	1.35
Tier1_GS Exclusive	Overlap	1.00	1.27	inf	1.56	1.99
Overlap	Exclusives	0.62	255734686404754.00	4.00	2.61	5.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_exp22 Exclusive	Tier1_GS	0.00	0.82	4.82	2.16	2.43
Tier1_GS Exclusive	82_exp22	0.01	1.31	3.11	1.08	4.55
82_exp22 Exclusive	Tier1_GS Exclusive	0.00	1.55	3.62	2.35	3.39
Tier1_GS Exclusive	82_exp22 Exclusive	0.01	0.72	0.91	1.35	1.34
82_exp22 Exclusive	Overlap	0.00	-0.50	-1003679365728397.00	-0.38	0.21
Tier1_GS Exclusive	Overlap	0.02	15.82	151272923003761312.00	33.85	61.87
Overlap	Exclusives	0.02	10023142929014320.00	14.11	9.50	9.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_exp22 Exclusive	81	79	RFPL2;ZNF705E
Tier1_GS Exclusive	30	29	MS4A
Overlap	1	1