Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
428AD_Bra3-6_RandomSet2_450HC_Bra3-6	Ismael_14_AD	7.15e-01	8.91e-01	7.68e-01	4.72e-02
Ismael_14_AD	428AD_Bra3-6_RandomSet2_450HC_Bra3-6	5.15e-01	6.09e-01	2.46e-02	5.28e-01



Evaluating how well 428AD_Bra3-6_RandomSet2_450HC_Bra3-6 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
428AD_Bra3-6_RandomSet2_450HC_Bra3-6	Ismael_14_AD	0.65	0.22	0.21	0.05	1.68
Ismael_14_AD	428AD_Bra3-6_RandomSet2_450HC_Bra3-6	0.50	1.00	0.74	0.61	0.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
428AD_Bra3-6_RandomSet2_450HC_Bra3-6	Ismael_14_AD	0.00	-0.01	-0.23	-0.26	-0.07
Ismael_14_AD	428AD_Bra3-6_RandomSet2_450HC_Bra3-6	0.00	-0.10	-0.06	-0.23	-0.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
428AD_Bra3-6_RandomSet2_450HC_Bra3-6	35	35	
Ismael_14_AD	14	14