Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	tier2_gs	9.84e-01	8.75e-01	4.30e-01	1.50e-01
tier2_gs	35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	9.53e-01	7.42e-01	4.17e-01	6.75e-01



Evaluating how well 35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	tier2_gs	0.58	-0.26	0.01	-0.41	1.95
tier2_gs	35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	0.47	0.06	-0.39	-0.44	-0.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	tier2_gs	0.00	-0.48	-0.09	-0.61	0.33
tier2_gs	35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	0.00	-0.29	-0.69	-0.23	-0.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	35	35	
tier2_gs	46	43	TNSF13;TNSF12;IGH