Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	Fuma_110	3.80e-01	3.43e-01	6.72e-01	2.35e-05
Fuma_110	35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	3.57e-01	4.25e-01	3.05e-01	7.20e-01



Evaluating how well 35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6 genes are linked to Fuma_110 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	Fuma_110	0.59	0.54	1.91	0.49	3.44
Fuma_110	35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	0.51	1.75	0.59	0.51	0.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	Fuma_110	0.01	-0.13	0.66	-0.38	1.17
Fuma_110	35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	0.00	-0.14	-0.22	-0.15	-0.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
35_negative_428AD_Bra3-6_RandomSet2_450HC_Bra3-6	35	35	
Fuma_110	110	105	LINC00158;SLC8A1-AS1;MIR302F;PCDH11Y;D21S2088E