Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 118_sigma_supercent Exclusive 274_longevity 1.49e-01 7.97e-01 1.17e-07 2.61e-08 274_longevity Exclusive 118_sigma_supercent 2.40e-04 2.29e-01 5.32e-05 8.34e-04 118_sigma_supercent Exclusive 274_longevity Exclusive 1.68e-01 7.66e-01 3.74e-08 1.81e-08 274_longevity Exclusive 118_sigma_supercent Exclusive 1.57e-04 2.21e-01 1.05e-04 7.28e-04 118_sigma_supercent Exclusive Overlap 6.73e-01 9.31e-01 1.98e-01 3.17e-01 274_longevity Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 3.74e-07 9.92e-11 8.89e-58 3.76e-17 Evaluating how well 118_sigma_supercent genes are linked to 274_longevity genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 118_sigma_supercent Exclusive 274_longevity 0.66 1.02 0.82 -0.82 5.79 274_longevity Exclusive 118_sigma_supercent 0.43 -0.06 0.85 0.08 -2.69 118_sigma_supercent Exclusive 274_longevity Exclusive 0.66 0.56 0.94 -0.87 6.84 274_longevity Exclusive 118_sigma_supercent Exclusive 0.42 -0.29 0.84 -0.21 -2.66 118_sigma_supercent Exclusive Overlap 0.80 -0.06 -0.45 -0.55 1.12 274_longevity Exclusive Overlap 1.00 1.62 1.33 1.11 1.57 Overlap Exclusives 0.64 1.55 6.60 2.13 8.30 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 118_sigma_supercent Exclusive 274_longevity 0.01 1.38 0.05 -0.89 4.03 274_longevity Exclusive 118_sigma_supercent 0.01 2.48 2.85 1.05 -0.87 118_sigma_supercent Exclusive 274_longevity Exclusive 0.01 0.87 0.18 -0.98 3.98 274_longevity Exclusive 118_sigma_supercent Exclusive 0.00 0.35 0.97 -0.19 -0.90 118_sigma_supercent Exclusive Overlap 0.00 -0.25 -0.95 -0.51 -0.10 274_longevity Exclusive Overlap 0.06 143.57 86.44 71.01 198.77 Overlap Exclusives 0.03 1.86 12.74 3.10 14.35 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 118_sigma_supercent Exclusive 117 114 PKD1L2;AKR7L;CTD-3088G3.8 274_longevity Exclusive 163 136 RHEB,RHOA,RICTOR,RPS6,RPS6KB1,SGK1,POLDIP3,SREBF1,TSC1,TSC2,ULK1,YY1,EIF4EBP1,AKT1,ATG101,ATG13,DEPTOR,EIF4B,EIF4E,RB1CC1,FOXO1,FOXO3,HIF1A,MLST8,LAMTOR3,MAPKAP1,MTOR,LAMTOR2,CDKN2C,PPARGC1A,PRKCA,PPARG,AKT1S1,PRR5,PRR5L,RRAGA,RRAGB,RRAGC,RRAGD,RPTOR;LINC01237;APOE,HRAS,CERS1;HSPA1B,HSPA1A,HSPA1L;GSTT1;TERC;nan;LMNA,SEMA4A;AFG1L,FOXO3;LINC02227;LOC105375494;LOC107987209;DBT,DLD,UBE4B;MTTP,CETP,APOC3,ADIPOQ;HTR1F,RAD51D,LARGE1,TBL1XR1,PLEKHA7,KIF13B,WWOX,CSF1R,SLC4A4,LINC02032,LOC105378178,PROM1,TMEM151B,SLC6A7,ENOX1,C2,C20orf78,NFKB1,CTNNA2,GSG1L,RAD51B,SYNE1,PITPNM3,TRIM25,TENM4,ADAMTSL1,SGSH,PKNOX2,ZBTB20,LOC105370656,LOC107986178,ITGA1,NT5DC1,TOMM40,BTG3,PLXNA4,CMAHP,DLGAP5,LRP1B,SYT13,WRN,SEMA6A,EIF4E3,HS3ST3B1,C20orf194,LINC02045,SORCS1,PGPEP1,SOCS2,LINC02391,EQTN,CADM1,LOC105378852,FAS,DOCK2,NR3C1,LOC107985988,THSD7B,LINC01234,TUSC3,LINC00032,MIR4500HG,LOC102723834,LINC01250,MYT1L,LINGO2,CSMD3,BTBD19,CDKN2B-AS1,LINC02463,UBE2H,IL12A,LINC01258,CTNND2,LOC341056,LOC107985305,SUMF1,LOC105373220,TNFRSF11A,ESRRG,PHYHIP,TBXAS1,DCPS,APBB2,ATXN7L3B,LOC400655,DSG1-AS1,LINC02095,BTNL2,SLC25A21,BABAM2,LY86,CDKN2B,LOC102723654,PRKN,SNAP25-AS1,LOC105370031,PAPD5,CCDC88C,CTNNA3,PTAR1,FGFR1,CHST11,PREX1,ERGIC1,WDR72,LMNA,LMX1B,EPB41L4B,TMEM2,EBF3,RNF219-AS1,DZIP3,OGDH,XDH,GPC6,XKR6,CGNL1,SOD2,LOC107984303,LOC387770,PCNX2,LOC105377865,MYO9B,LOC105377739,AIF1,TOX,CLYBL,RYR3,ZWINT,SORCS2,CDK6,DOCK8,LINC01182,TTC27,GBA3,LOC105372161,TNFSF8,TTC6,NAV2,NR2F2-AS1,FHIT,ANGEL1,ASIC2,SH2D4A,LOC101927668,LY6G6F,RARB,C9orf3,MKL1,PPP2R2B,LYPLAL1,NBEA,BHLHE41,CAMTA1,KCTD1,LOC105373714,RNF145,CCDC85A,LOC105373215,LOC105375731,GATA4,KLRF1,CDK14;ADA,TNF;PPP1R26-AS1;APOC1,TOMM40;TP53,GSTT1;TOMM40,APOE;IGF1R,IRS2,UCP2;RNR2;METTL1,EEF1AKMT3,TSFM;AKT1,AKT3,FOXO4,IGF2,INS,PIK3CA,SGK1,SGK3,YWHAG,POT1;LOC100631378;LOC105378102;HSPA1B,HSPA1L,HSPA1A Overlap 1 1