Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
43_BetaPos_Reactome	358_longeviry	1.14e-04	1.49e-01	1.94e-04	2.16e-12
358_longeviry	43_BetaPos_Reactome	5.59e-03	3.63e-03	8.23e-04	1.73e-02



Evaluating how well 43_BetaPos_Reactome genes are linked to 358_longeviry genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
43_BetaPos_Reactome	358_longeviry	0.64	0.88	1.59	0.53	8.66
358_longeviry	43_BetaPos_Reactome	0.42	-0.49	-2.22	-1.42	-2.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
43_BetaPos_Reactome	358_longeviry	0.02	0.50	1.51	0.14	5.90
358_longeviry	43_BetaPos_Reactome	0.00	0.35	-0.13	-0.27	-0.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
43_BetaPos_Reactome	43	43	
358_longeviry	358	307	LINC02391;GBA3;LOC105378102;LOC105373215;LINC00032;LOC105373220;LOC107985305;LINC02095;SNAP25-AS1;LINC02045;TERC;LOC105373714;LOC102723834;LOC105370656;LOC102723654;RNF219-AS1;LOC400655;LOC107986178;LOC105377865;DSG1-AS1;LOC105377739;CDKN2B-AS1;RNR2;LOC105375731;LINC01237;LOC107984303;LOC107987209;LINC01234;LOC105372161;LINC02463;LINC01258;PPP1R26-AS1;LOC341056;LOC387770;LOC105370031;LOC105378178;LOC101927668;LOC105375494;LINC02227;LOC107985988;LOC100631378;TTC6;NR2F2-AS1;LINC02032;MIR4500HG;C20orf78;LINC01250;CMAHP;LINC01182;LOC105378852;GSTT1