Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_R4_selected2 Exclusive	Regulome_R4_selected2	3.77e-01	5.80e-01	5.34e-01	1.01e-01
Regulome_R4_selected2 Exclusive	EA_R4_selected2	3.76e-01	2.37e-01	6.66e-02	2.86e-01
EA_R4_selected2 Exclusive	Regulome_R4_selected2 Exclusive	2.45e-01	4.89e-01	2.91e-01	2.63e-02
Regulome_R4_selected2 Exclusive	EA_R4_selected2 Exclusive	5.29e-01	4.35e-01	1.77e-01	6.75e-01
EA_R4_selected2 Exclusive	Overlap	8.90e-01	6.27e-01	8.30e-01	4.13e-01
Regulome_R4_selected2 Exclusive	Overlap	9.14e-02	1.18e-01	1.07e-01	1.70e-01
Overlap	Exclusives	1.98e-01	4.06e-01	7.49e-02	2.35e-01



Evaluating how well EA_R4_selected2 genes are linked to Regulome_R4_selected2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_R4_selected2 Exclusive	Regulome_R4_selected2	0.55	1.96	1.08	1.49	2.20
Regulome_R4_selected2 Exclusive	EA_R4_selected2	0.53	1.37	1.39	1.41	1.20
EA_R4_selected2 Exclusive	Regulome_R4_selected2 Exclusive	0.56	1.86	1.17	1.69	2.60
Regulome_R4_selected2 Exclusive	EA_R4_selected2 Exclusive	0.52	0.83	0.87	1.24	0.54
EA_R4_selected2 Exclusive	Overlap	0.43	-0.08	-0.72	-0.26	-0.61
Regulome_R4_selected2 Exclusive	Overlap	0.59	1.95	1.27	1.64	1.05
Overlap	Exclusives	0.54	0.67	1.20	1.01	2.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_R4_selected2 Exclusive	Regulome_R4_selected2	0.01	1.59	0.59	1.05	1.11
Regulome_R4_selected2 Exclusive	EA_R4_selected2	0.01	3.97	1.89	3.86	3.75
EA_R4_selected2 Exclusive	Regulome_R4_selected2 Exclusive	0.01	1.48	0.82	1.63	1.76
Regulome_R4_selected2 Exclusive	EA_R4_selected2 Exclusive	0.01	2.71	0.76	2.59	0.81
EA_R4_selected2 Exclusive	Overlap	0.00	0.03	-0.37	-0.16	0.10
Regulome_R4_selected2 Exclusive	Overlap	0.00	5.73	5.45	3.06	4.99
Overlap	Exclusives	0.02	0.91	1.68	1.28	1.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_R4_selected2 Exclusive	107	105	EDDM13;CHURC1-FNTB
Regulome_R4_selected2 Exclusive	175	168	LINC02210-CRHR1;PRAMEF15;TNFSF12-TNFSF13;TMEM191C;AL451062.3;TAF11L13;AC005779.2
Overlap	9	9