Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Regulome_R4_selected2 Exclusive Regulome_score_R3_selected 4.86e-01 4.73e-01 4.46e-01 1.23e-01 Regulome_score_R3_selected Exclusive Regulome_R4_selected2 6.70e-01 8.82e-01 2.46e-01 4.09e-01 Regulome_R4_selected2 Exclusive Regulome_score_R3_selected Exclusive 4.18e-01 3.10e-01 4.75e-01 2.77e-01 Regulome_score_R3_selected Exclusive Regulome_R4_selected2 Exclusive 4.41e-01 8.61e-01 3.69e-01 5.28e-01 Regulome_R4_selected2 Exclusive Overlap 7.38e-01 6.31e-01 4.97e-01 1.04e-01 Regulome_score_R3_selected Exclusive Overlap 8.67e-01 5.00e-01 3.80e-01 7.25e-02 Overlap Exclusives 3.83e-01 8.06e-01 1.78e-03 6.95e-02 Evaluating how well Regulome_R4_selected2 genes are linked to Regulome_score_R3_selected genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Regulome_R4_selected2 Exclusive Regulome_score_R3_selected 0.55 0.91 0.18 0.88 2.12 Regulome_score_R3_selected Exclusive Regulome_R4_selected2 0.54 0.64 0.65 0.86 2.01 Regulome_R4_selected2 Exclusive Regulome_score_R3_selected Exclusive 0.53 0.83 -0.26 0.53 1.27 Regulome_score_R3_selected Exclusive Regulome_R4_selected2 Exclusive 0.53 0.04 0.17 0.51 1.21 Regulome_R4_selected2 Exclusive Overlap 0.61 0.89 0.78 0.93 1.99 Regulome_score_R3_selected Exclusive Overlap 0.61 0.85 0.78 1.00 1.82 Overlap Exclusives 0.54 0.53 0.81 1.01 2.40 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Regulome_R4_selected2 Exclusive Regulome_score_R3_selected 0.01 0.66 0.40 0.95 2.46 Regulome_score_R3_selected Exclusive Regulome_R4_selected2 0.01 0.92 1.02 1.28 1.39 Regulome_R4_selected2 Exclusive Regulome_score_R3_selected Exclusive 0.01 0.12 -0.58 0.19 0.18 Regulome_score_R3_selected Exclusive Regulome_R4_selected2 Exclusive 0.01 0.11 0.23 0.52 0.16 Regulome_R4_selected2 Exclusive Overlap 0.00 4.41 4.69 4.90 4.08 Regulome_score_R3_selected Exclusive Overlap 0.00 0.75 1.48 0.96 1.52 Overlap Exclusives 0.02 1.63 1.58 1.76 3.19 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Regulome_R4_selected2 Exclusive 160 153 PRAMEF15;AL451062.3;TMEM191C;TAF11L13;TNFSF12-TNFSF13;AC005779.2;LINC02210-CRHR1 Regulome_score_R3_selected Exclusive 128 120 SPECC1L-ADORA2A;CCDC187;AC233992.2;CLEC20A;2-Mar;MARCOL;9-Mar;AC010197.2 Overlap 24 24